diff --git a/frappe/core/doctype/doctype/doctype.py b/frappe/core/doctype/doctype/doctype.py
index 22f9620ba6..77482dc8b0 100644
--- a/frappe/core/doctype/doctype/doctype.py
+++ b/frappe/core/doctype/doctype/doctype.py
@@ -1278,6 +1278,8 @@ def validate_fields(meta: Meta):
 		validate_column_name(fieldname)
 
 	def check_invalid_fieldnames(docname, fieldname):
+		RESERVED_DOCFIELD_NAMES = frozenset(("autoname",))
+
 		if fieldname in RESERVED_KEYWORDS:
 			frappe.throw(
 				_("{0}: fieldname cannot be set to reserved keyword {1}").format(
@@ -1287,6 +1289,15 @@ def validate_fields(meta: Meta):
 				title=_("Invalid Fieldname"),
 			)
 
+		if fieldname in RESERVED_DOCFIELD_NAMES and docname != "DocType":
+			frappe.throw(
+				_("{0}: fieldname cannot be set to reserved field {1} in DocType").format(
+					frappe.bold(docname),
+					frappe.bold(fieldname),
+				),
+				title=_("Invalid Fieldname"),
+			)
+
 	def check_unique_fieldname(docname, fieldname):
 		duplicates = list(
 			filter(None, map(lambda df: (df.fieldname == fieldname and str(df.idx)) or None, fields))
diff --git a/frappe/model/base_document.py b/frappe/model/base_document.py
index ebfe364b60..039fc78187 100644
--- a/frappe/model/base_document.py
+++ b/frappe/model/base_document.py
@@ -2,6 +2,7 @@
 # License: MIT. See LICENSE
 import datetime
 import json
+import keyword
 import weakref
 from types import MappingProxyType
 from typing import TYPE_CHECKING, TypeVar