diff --git a/frappe/core/doctype/doctype/doctype.json b/frappe/core/doctype/doctype/doctype.json
index 0f97b077ab..c285c6ffec 100644
--- a/frappe/core/doctype/doctype/doctype.json
+++ b/frappe/core/doctype/doctype/doctype.json
@@ -570,7 +570,7 @@
    "fieldtype": "Select",
    "label": "Naming Rule",
    "length": 40,
-   "options": "\nSet by user\nAutoincrement\nBy fieldname\nBy \"Naming Series\" field\nExpression\nExpression (old style)\nRandom\nBy script"
+   "options": "\nSet by user\nAutoincrement\nBy fieldname\nBy \"Naming Series\" field\nExpression\nExpression (old style)\nRandom\nUUID\nBy script"
   },
   {
    "fieldname": "migration_hash",
@@ -750,7 +750,7 @@
    "link_fieldname": "reference_doctype"
   }
  ],
- "modified": "2024-03-23 16:03:21.405959",
+ "modified": "2024-03-29 16:09:26.114720",
  "modified_by": "Administrator",
  "module": "Core",
  "name": "DocType",
diff --git a/frappe/core/doctype/doctype/doctype.py b/frappe/core/doctype/doctype/doctype.py
index 7237992fdf..7c29792778 100644
--- a/frappe/core/doctype/doctype/doctype.py
+++ b/frappe/core/doctype/doctype/doctype.py
@@ -147,6 +147,7 @@ class DocType(Document):
 			"Expression",
 			"Expression (old style)",
 			"Random",
+			"UUID",
 			"By script",
 		]
 		nsm_parent_field: DF.Data | None
diff --git a/frappe/database/mariadb/schema.py b/frappe/database/mariadb/schema.py
index 73a92dfa4a..d1ec513026 100644
--- a/frappe/database/mariadb/schema.py
+++ b/frappe/database/mariadb/schema.py
@@ -47,6 +47,9 @@ class MariaDBTable(DBTable):
 			# issue link: https://jira.mariadb.org/browse/MDEV-20070
 			name_column = "name bigint primary key"
 
+		elif not self.meta.issingle and self.meta.autoname == "UUID":
+			name_column = "name uuid primary key"
+
 		additional_definitions = ",\n".join(additional_definitions)
 
 		# create table
@@ -76,6 +79,9 @@ class MariaDBTable(DBTable):
 			f"MODIFY `{col.fieldname}` {col.get_definition(for_modification=True)}"
 			for col in columns_to_modify
 		]
+		if alter_pk := self.alter_primary_key():
+			modify_column_query.append(alter_pk)
+
 		modify_column_query.extend(
 			[f"ADD UNIQUE INDEX IF NOT EXISTS {col.fieldname} (`{col.fieldname}`)" for col in self.add_unique]
 		)
@@ -138,3 +144,20 @@ class MariaDBTable(DBTable):
 				)
 
 			raise
+
+	def alter_primary_key(self) -> str | None:
+		# If there are no values in table allow migrating to UUID from varchar
+		autoname = self.meta.autoname
+		if autoname == "UUID" and frappe.db.get_column_type(self.doctype, "name") != "uuid":
+			if not frappe.db.get_value(self.doctype, {}, order_by=None):
+				return "modify name uuid"
+			else:
+				frappe.throw(
+					_("Primary key of doctype {0} can not be changed as there are existing values.").format(
+						self.doctype
+					)
+				)
+
+		# Reverting from UUID to VARCHAR
+		if autoname != "UUID" and frappe.db.get_column_type(self.doctype, "name") == "uuid":
+			return f"modify name varchar({frappe.db.VARCHAR_LEN})"
diff --git a/frappe/database/postgres/schema.py b/frappe/database/postgres/schema.py
index 018de93f41..926f9e0edd 100644
--- a/frappe/database/postgres/schema.py
+++ b/frappe/database/postgres/schema.py
@@ -34,6 +34,9 @@ class PostgresTable(DBTable):
 			frappe.db.create_sequence(self.doctype, check_not_exists=True)
 			name_column = "name bigint primary key"
 
+		elif not self.meta.issingle and self.meta.autoname == "UUID":
+			name_column = "name uuid primary key"
+
 		# TODO: set docstatus length
 		# create table
 		frappe.db.sql(
@@ -91,6 +94,9 @@ class PostgresTable(DBTable):
 				)
 			)
 
+		if alter_pk := self.alter_primary_key():
+			query.append(alter_pk)
+
 		for col in self.set_default:
 			if col.fieldname == "name":
 				continue
@@ -181,3 +187,20 @@ class PostgresTable(DBTable):
 				)
 			else:
 				raise e
+
+	def alter_primary_key(self) -> str | None:
+		# If there are no values in table allow migrating to UUID from varchar
+		autoname = self.meta.autoname
+		if autoname == "UUID" and frappe.db.get_column_type(self.doctype, "name") != "uuid":
+			if not frappe.db.get_value(self.doctype, {}, order_by=None):
+				return "alter column `name` TYPE uuid USING name::uuid"
+			else:
+				frappe.throw(
+					_("Primary key of doctype {0} can not be changed as there are existing values.").format(
+						self.doctype
+					)
+				)
+
+		# Reverting from UUID to VARCHAR
+		if autoname != "UUID" and frappe.db.get_column_type(self.doctype, "name") == "uuid":
+			return f"alter column `name` TYPE varchar({frappe.db.VARCHAR_LEN})"
diff --git a/frappe/model/naming.py b/frappe/model/naming.py
index 7dabb3d80d..ddbea52c1d 100644
--- a/frappe/model/naming.py
+++ b/frappe/model/naming.py
@@ -4,10 +4,12 @@
 import base64
 import datetime
 import re
-import struct
 import time
 from collections.abc import Callable
 from typing import TYPE_CHECKING, Optional
+from uuid import UUID
+
+import uuid_utils
 
 import frappe
 from frappe import _
@@ -39,6 +41,10 @@ class InvalidNamingSeriesError(frappe.ValidationError):
 	pass
 
 
+class InvalidUUIDValue(frappe.ValidationError):
+	pass
+
+
 class NamingSeries:
 	__slots__ = ("series",)
 
@@ -142,13 +148,25 @@ def set_new_name(doc):
 	meta = frappe.get_meta(doc.doctype)
 	autoname = meta.autoname or ""
 
-	if autoname.lower() != "prompt" and not frappe.flags.in_import:
+	if autoname.lower() not in ("prompt", "uuid") and not frappe.flags.in_import:
 		doc.name = None
 
 	if is_autoincremented(doc.doctype, meta):
 		doc.name = frappe.db.get_next_sequence_val(doc.doctype)
 		return
 
+	if meta.autoname == "UUID":
+		if not doc.name:
+			doc.name = str(uuid_utils.uuid7())
+		elif isinstance(doc.name, UUID | uuid_utils.UUID):
+			doc.name = str(doc.name)
+		elif isinstance(doc.name, str):  # validate
+			try:
+				UUID(doc.name)
+			except ValueError:
+				frappe.throw(_("Invalid value specified for UUID: {}").format(doc.name), InvalidUUIDValue)
+		return
+
 	if getattr(doc, "amended_from", None):
 		_set_amended_name(doc)
 		if doc.name:
@@ -179,10 +197,7 @@ def is_autoincremented(doctype: str, meta: Optional["Meta"] = None) -> bool:
 	if not meta:
 		meta = frappe.get_meta(doctype)
 
-	if not getattr(meta, "issingle", False) and meta.autoname == "autoincrement":
-		return True
-
-	return False
+	return not getattr(meta, "issingle", False) and meta.autoname == "autoincrement"
 
 
 def set_name_from_naming_options(autoname, doc):
diff --git a/frappe/public/js/frappe/doctype/index.js b/frappe/public/js/frappe/doctype/index.js
index 5b072d6bfa..4d8e437c1b 100644
--- a/frappe/public/js/frappe/doctype/index.js
+++ b/frappe/public/js/frappe/doctype/index.js
@@ -78,6 +78,7 @@ frappe.model.DocTypeController = class DocTypeController extends frappe.ui.form.
 				Expression: "format:",
 				"Expression (sld style)": "",
 				Random: "hash",
+				UUID: "UUID",
 				"By script": "",
 			};
 			this.frm.set_value(
diff --git a/frappe/tests/test_db_update.py b/frappe/tests/test_db_update.py
index 780be92fda..68a22e0de2 100644
--- a/frappe/tests/test_db_update.py
+++ b/frappe/tests/test_db_update.py
@@ -139,6 +139,20 @@ class TestDBUpdate(FrappeTestCase):
 		doctype.delete()
 		frappe.db.commit()
 
+	def test_uuid_varchar_migration(self):
+		doctype = new_doctype().insert()
+		doctype.autoname = "UUID"
+		doctype.save()
+		self.assertEqual(frappe.db.get_column_type(doctype.name, "name"), "uuid")
+
+		doc = frappe.new_doc(doctype.name).insert()
+
+		doctype.autoname = "hash"
+		doctype.save()
+		varchar = "varchar" if frappe.db.db_type == "mariadb" else "character varying"
+		self.assertIn(varchar, frappe.db.get_column_type(doctype.name, "name"))
+		doc.reload()  # ensure that docs are still accesible
+
 
 def get_fieldtype_from_def(field_def):
 	fieldtuple = frappe.db.type_map.get(field_def.fieldtype, ("", 0))
diff --git a/frappe/tests/test_document.py b/frappe/tests/test_document.py
index a707312103..dd76970903 100644
--- a/frappe/tests/test_document.py
+++ b/frappe/tests/test_document.py
@@ -9,7 +9,7 @@ from frappe.app import make_form_dict
 from frappe.core.doctype.doctype.test_doctype import new_doctype
 from frappe.desk.doctype.note.note import Note
 from frappe.model.naming import make_autoname, parse_naming_series, revert_series_if_last
-from frappe.tests.utils import FrappeTestCase, timeout
+from frappe.tests.utils import FrappeTestCase
 from frappe.utils import cint, now_datetime, set_request
 from frappe.website.serve import get_response
 
diff --git a/frappe/tests/test_naming.py b/frappe/tests/test_naming.py
index aa2c091fac..b2e3c3a18a 100644
--- a/frappe/tests/test_naming.py
+++ b/frappe/tests/test_naming.py
@@ -2,13 +2,16 @@
 # License: MIT. See LICENSE
 
 import time
+from uuid import UUID
 
+import uuid_utils
 from tenacity import retry, retry_if_exception_type, stop_after_attempt, wait_full_jitter
 
 import frappe
 from frappe.core.doctype.doctype.test_doctype import new_doctype
 from frappe.model.naming import (
 	InvalidNamingSeriesError,
+	InvalidUUIDValue,
 	NamingSeries,
 	append_number_if_name_exists,
 	determine_consecutive_week_number,
@@ -407,6 +410,27 @@ class TestNaming(FrappeTestCase):
 			names.append(make_autoname("hash"))
 		self.assertEqual(names, sorted(names))
 
+	def test_uuid_naming(self):
+		uuid_doctype = new_doctype(autoname="UUID").insert().name
+		self.assertEqual("uuid", frappe.db.get_column_type(uuid_doctype, "name"))
+
+		# Auto set names
+		document = frappe.new_doc(uuid_doctype).insert()
+		uid = UUID(document.name)
+		self.assertEqual(uid.version, 7)  # Default version
+
+		# Applications can specify UUID themselves, useful for APIs to set name themselves.
+		for uid in (uuid_utils.uuid4(), uuid_utils.uuid7()):
+			doc = frappe.new_doc(uuid_doctype, name=uid).insert()
+			self.assertEqual(doc.name, str(uid))
+
+		# Can specify valid UUID strings too
+		for uid in (uuid_utils.uuid4(), uuid_utils.uuid7()):
+			doc = frappe.new_doc(uuid_doctype, name=str(uid)).insert()
+			self.assertEqual(doc.name, str(uid))
+
+		self.assertRaises(InvalidUUIDValue, frappe.new_doc(uuid_doctype, name="XYZ").insert)
+
 
 def parse_naming_series_variable(doc, variable):
 	if variable == "PM":
diff --git a/pyproject.toml b/pyproject.toml
index 14289d1a72..734ffef6dc 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -73,6 +73,7 @@ dependencies = [
     "terminaltables~=3.1.10",
     "traceback-with-variables~=2.0.4",
     "typing_extensions>=4.6.1,<5",
+    "uuid-utils~=0.6.1",
     "xlrd~=2.0.1",
     "zxcvbn~=4.4.28",
     "markdownify~=0.11.6",